A large Melbourne study has demonstrated thatuse of oral bisphosphonates dramatically raises the odds of delayed healing after dental surgery as well as subsequent jaw osteonecrosis, according to Endocrinology Update.

Data from more than 4,200 dental patients and controls from various hospitals showed a 13-fold increased risk of delayed healing after a dental intervention in those using oral bisphosphonates. After adjustment for smoking, the researchers from the University of Melbourne found an 11.6-fold raised risk with bisphosphonates.

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