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ACTIVA BioACTIVE-CEMENT Receives Top Rating from REALITY

Posted on Wednesday, October 10, 2018

ACTIVA BioACTIVE-CEMENT received the top rating from REALITY in the “Resin Cements – Dual-Cured Only – Self-Adhesive” category.

Some traditional, non-bioactive dental cements can wash away over time, leaving teeth vulnerable to acid attack and additional decay. The result can be painful and costly for patients, who find themselves needing replacement crowns or, if the decay is extensive, a root canal treatment or even a dental implant.

Bioactive cements offer a better solution for the patient:

Bioactive dental cements help protect teeth from acid attack caused by dietary sugars. ACTIVA BioACTIVE-CEMENT responds to pH changes in the oral environment through a release and recharge of calcium, phosphate and fluoride.

This unique chemistry supports the natural remineralization process with the release of calcium, phosphate and fluoride and helps form a seal between the material and the tooth.

This protective seal helps prevent new cavities from forming under dental crowns and bridges.

According to the REALITY review, dentist evaluators were generally pleased with the consistency and handling of ACTIVA BioACTIVE-CEMENT. Evaluators found that the cement “cleans up nicely” and used the bioactive dental cement for both single and multi-unit restorations. REALITY reported “virtually no dislodgements and post-cementation sensitivity.” One evaluator used ACTIVA BioACTIVE-CEMENT to salvage failing crowns for medically compromised patients.

ACTIVA™ BioACTIVE-CEMENT is an esthetic bioactive dental cement that imitates the physical and chemical properties of teeth. It contains no Bisphenol A, no Bis-GMA and no BPA derivatives.







Internationally Renowned Pediatric Dentist Appointed to BIOLASE Board of Directors

Posted on Tuesday, October 9, 2018

BIOLASE, Inc. (NASDAQ: BIOL), the global leader in dental lasers, today announced that Dr. Elaine C. Wagner, a retired Rear Admiral with 33 years of service in the United States Navy, has been appointed to its Board of Directors.

"Dr. Wagner is a renowned leader in the practice of pediatric dentistry, and her vast experience combined with strong management skills will be invaluable to BIOLASE and to our customers," said Todd Norbe, president and chief executive officer. "We are excited to have her join our board and look forward to her contributions as we continue to focus on making lasers the standard of care in pediatric dentistry and advancing dentistry through laser technology."

Dr. Wagner is the first female board-certified pediatric dentist to be promoted to the rank of Rear Admiral, upper-half, in the United States Navy Dental Corps. She completed residency at Riley Children's Hospital in Indianapolis in 1982 and was certified by the American Board of Pediatric Dentistry in 1991. After 18 months in private practice, Dr. Wagner was commissioned in the US Navy in 1983. After distinguished tours in San Diego and the Philippines, she was assigned to the National Naval Medical Center as the Dental Department's first pediatric dentist in 1992. Following that assignment, her career carried her through many distinguished Navy dental positions, including a year as a Commanding Officer at the Navy's Expeditionary Medical Facility (EMF) in Kuwait. In 2009, Dr. Wagner assumed command of the Naval Health Clinic New England. The following year, she assumed the duties as the director, Medical Resources Plans and Policy Division, Office of the Chief of Naval Operations code N931 and chief, Navy Dental Corps. From 2011 to 2014, she served as the commander of Navy Medicine East and Naval Medical Center Portsmouth, and as director of the Tidewater Enhanced Multi-Service Market. From 2014 until she retired in 2017, Dr. Wagner served at the Navy's Bureau of Medicine and Surgery in Falls Church, Virginia as the Director for Readiness and Health.

"I am delighted to be joining BIOLASE at this exciting time," said Dr. Wagner. "I look forward to advancing dentistry through laser technology and believe by doing this, we can help raise an entire generation of people who are not afraid of going to the dentist."

Dr. Wagner currently serves as the Registrar/Executive Director for the International College of Dentists USA Section. Her military decorations and awards include the Legion of Merit with three gold stars, Meritorious Service Medal with three gold stars, Navy and Marine Corps Commendation Medal with three gold stars, and the Navy and Marine Corps Achievement Medal with two gold stars.

With the appointment of Wagner, BIOLASE now has six board members, with three of the board members having combined dental industry experience of 90 years.

About BIOLASE

BIOLASE, Inc. is a medical device company that develops, manufactures, markets, and sells laser systems in dentistry and medicine and also markets, sells, and distributes dental imaging equipment, including three-dimensional CAD/CAM intra-oral scanners and digital dentistry software. BIOLASE's products advance the practice of dentistry and medicine for patients and healthcare professionals. BIOLASE's proprietary laser products incorporate approximately 244 patented and 74 patent-pending technologies designed to provide biologically clinically superior performance with less pain and faster recovery times. BIOLASE's innovative products provide cutting-edge technology at competitive prices to deliver the best results for dentists and patients. BIOLASE's principal products are revolutionary dental laser systems that perform a broad range of dental procedures, including cosmetic and complex surgical applications, and a full line of dental imaging equipment. BIOLASE has sold over 37,600 laser systems to date in over 90 countries around the world. Laser products under development address BIOLASE's core dental market and other adjacent medical and consumer markets. 







International Airway Symposium 2019

Posted on Monday, October 8, 2018

The 3rd Annual International Airway Symposium will be in Downtown St. Petersburg, Florida on January 18-19, 2019. Combining science with the practical application of diagnosing, evaluating, and treating airway and sleep-disordered breathing.  Interact with and learn from world authorities on airway and breathing disorders.

During this course:

• Discover the impact and evolution of airway and breathing disorders from childhood through adulthood

• Connect the relationship between airway disorders and occlusion

• Learn how the experts diagnose, evaluate and treat these disorders

• Understand where we go from here and how this fits into your practice

Featured speakers include: DeWitt Wilkerson, DMD, Kevin Boyd, DDS, Barry Raphael, DMD, and Marianna Evans, DMD.

Register: 800-952-2178 or thedawsonacademy.com/airway







Komet USA Expands Line of Crown-Prep Diamonds

Posted on Monday, October 8, 2018

With its launch of two new egg-shaped diamond instruments, Komet USA continues to address the needs and challenges of crown-preparation procedures, introducing the paired, egg-shaped S6379E.FG.029 and 8379E.FG.029 diamonds. The coarse-grit S6379E diamond is ideal for primary preparation, and when used in conjunction with the matching 8379E fine-grit finisher, the instrument produces the required preparation configuration with ease and confidence.

The instruments’ ideal size and geometry allow smooth material reduction and precise anatomical contouring when preparing the palatal surfaces of incisors and the occlusal surfaces of molars and premolars. In the laboratory, the instruments are especially suitable for making occlusal adjustments on veneer ceramics of porcelain-fused-to-metal crowns.

About Komet USA

Currently celebrating 95 years of unparalleled excellence in the dental industry, Komet is a recognized worldwide leader in the production of highly specialized dental burs, discs, diamonds, endodontic instruments, and accessories. Komet operates in the United States under the name Komet USA LLC. Komet sells direct to dental practitioners and dental laboratories, delivering orders quickly and efficiently from its state-of-the-art factory in Lemgo, Germany. The company’s U.S. headquarters is located in Rock Hill, South Carolina. For more information about Komet USA and the egg-shaped S6379E and 8379E crown-preparation diamonds, call 888-566-3887 or visit www.kometusa.com.







Komet USA Introduces New Sonic Tips for Crown Preparations

Posted on Monday, October 8, 2018

The Komet SonicLine instrument selection has been expanded to include two special Sonic tips for crown preparation, SF856.000.018 and SF878K.000.018, which correspond to Komet’s 856 (S6856.314.018) and 878K (S6878K.314.018) rotary crown-preparation diamonds, respectively. Sonic tip SF856.000.018 features a round tapered-chamfer configuration, while tip SF878K.000.018 provides a modified tapered-chamfer shape.

After supragingival preparation has been achieved with the diamond rotary instrument of matched shape, the corresponding Sonic tip is employed to produce a precisely positioned and finished prosthetic margin and to enhance interproximal finishing. The tips create exceptionally fine crown margins that are essential to a well-fitting, durable restoration.

When in operation, the Sonic crown-preparation tips produce an oscillating function that allows the crown margin to be gently and safely positioned while protecting the soft tissue, thus avoiding gingival trauma or hemorrhage that can compromise impression taking. The oscillating elliptical vibrations of the sonic tips also create an irregular surface structure of the crown core that promotes perfect penetration and adhesion for crown cementation.

Made in Germany with outstanding attention to engineering and clinical requirements, the SonicLine system comprises a comprehensive range of high-quality Sonic tips that cover a multitude of indications, including prophylaxis, veneer procedures, and the opening of fissures as well as crown-preparation cases. Special tip labeling allows the user to easily identify the correct tip for a specific procedure, and laser etching of the order number on the sonic tips facilitates ordering of additional tips as needs arise. The Sonic tips can withstand regular reprocessing in a washer/disinfector through use of a rinse adapter.

About Komet USA

Currently celebrating 95 years of unparalleled excellence in the dental industry, Komet is a recognized worldwide leader in the production of highly specialized dental burs, discs, diamonds, endodontic instruments, and accessories. Komet operates in the United States under the name Komet USA LLC. Komet sells direct to dental practitioners and dental laboratories, delivering orders quickly and efficiently from its state-of-the-art factory in Lemgo, Germany. The company’s U.S. headquarters is located in Rock Hill, South Carolina. For more information about Komet USA and Komet’s Crown Prep Sonic Tips, call 888-566-3887 or visit www.kometusa.com.

 







NYU Meyers Receives $3.47 Million NIH Grant to Improve Oral Health Among People with Dementia

Posted on Monday, October 8, 2018

The National Institute of Dental and Craniofacial Research and National Institute on Aging, both part of the National Institutes of Health, have awarded the NYU Rory Meyers College of Nursing with funding to improve the oral hygiene of people with mild dementia. The $3.47 million, five-year grant will be used to implement and study a unique oral health intervention involving family caregivers in New York and North Carolina.

Bei Wu from NYU Meyers is the contact principal investigator of the project. The other two co-principal investigators are Brenda Plassman from Duke Health and Ruth Anderson from the University of North Carolina at Chapel Hill. 

People with dementia, including Alzheimer’s disease, have significantly poorer oral health than do other older adults, including more plaque, more cavities, severe gum disease, and fewer teeth. Even individuals with mild dementia are at higher risk of poor oral health, and research suggests that inadequate oral hygiene practices are a major contributing factor.

Good oral hygiene—particularly routine tooth brushing and flossing—is a critical step in preventing the deterioration of oral health and general overall health for people with dementia. A few studies conducted in nursing homes have shown that with good oral hygiene, the oral health of people with dementia improves notably in a short period of time.

People with mild dementia often live at home and are cared for by family members, who supervise and help with daily activities, but often neglect oral hygiene. An intervention that incorporates both people with mild dementia and their caregivers to improve oral self-care could have long term oral health benefits for people with dementia.

Using results from a pilot study, the researchers developed an intervention to help family caregivers guide people with mild dementia in carrying out oral hygiene. The intervention is designed to work with the caregiver and individual with mild dementia to identify challenges in oral care, help them learn to solve them, and improve the ability of the person with dementia to engage in effective oral care.

“To our knowledge, this is the first oral health intervention to be conducted among community-dwelling people with mild dementia, and the results of our pilot study suggest that a caregiver-assisted intervention can improve oral health outcomes,” said Wu, the Dean’s Professor in Global Health at NYU Meyers and co-director of NYU Aging Incubator.

“Introducing an intervention when dementia is still mild is ideal, because people with mild dementia still have the ability to perform oral hygiene tasks with minimal assistance,” said Plassman, professor of psychiatry and behavioral sciences at Duke Health.

Through this new NIH funding, the research team will conduct a randomized control trial in New York City and North Carolina to test the oral health intervention. In addition to measuring whether the intervention improves oral hygiene, the researchers will also look at communication between people with dementia and their caregivers and will assess their oral health knowledge and confidence in their ability to improve their oral health.

“The team views the caregiver as a leader, guiding the individuals with mild dementia to maintain their independence in completing daily activities,” said Anderson, associate dean for research at UNC-Chapel Hill School of Nursing.

The research is funded under grant number U01DE027512-01.

About NYU Rory Meyers College of Nursing (@NYUNursing)

NYU Rory Meyers College of Nursing is a global leader in nursing and health. Founded in 1932, the College offers BS, MS, DNP, and PhD degree programs providing the educational foundation to prepare the next generation of nursing leaders and researchers. NYU Meyers has three programs ranked in the top 10 by U.S. News & World Report and is among the top 10 nursing schools receiving NIH funding, thanks to its research mission and commitment to innovative approaches to healthcare worldwide.







2019 Aruba Dental Conference Announced

Posted on Thursday, October 4, 2018

White sands, crystal waters, blue skies – and six of dentistry’s most knowledgeable speakers. Mix sunny relaxation with the latest in continuing education, and get inspired at the 5th Annual Aruba Dental Conference, presented by Clinician’s Choice! Happening January 21- February 2, 2019 at the Hyatt Regency Aruba Resort Spa and Casino, this year’s conference features an impressive line-up of lecturers, discussing the most up-to-date information in esthetic and restorative dentistry.

On day 1, Dr. Robert Lowe will discuss “Materials and Technologies That Will Enhance Your Restorative Practice” where he will cover a number of emerging materials and techniques that can expand the quantity and quality of services you offer to patients. Afterwards, Dr. Marc Geissberger will begin his fast-paced and informative session on “New Advances in Posterior Restorative Dentistry: Overcoming Common Pain Points, Pitfalls, and Problems in Private Practice” which includes clinical tips and techniques for mastering clinical procedures associated with Class II restorations, crown and bridge impressions and provisions, bonding, and Class IV restorations.

Day 2 begins with Dr. Robert Margeas discussing “Diagnosis and Treatment of the Worn Dentition” where he will show (with live demonstrations), how to create composite overlays and alter the vertical dimension to treat the worn dentition for long term bonding. Dr. Fred Peck will follow with his informative discussion on “Ensuring Success in Anterior Aesthetics” which features a step-by-step approach to accurately analyze a patient’s dental condition to then recreate a natural dentition and smile.

On day 3, the excitement continues as Dr. David K. Chan enlightens participants on how to “Achieve a Higher Level of Artistry with Anterior Composites… Predictably”. This course will give a detailed explanation of the criteria needed to achieve results that can seamlessly emulate natural teeth or mimic the beauty of porcelain restorations. Finishing the conference is Dr. Betsy Bakeman on “Creating Veneer Success”, covering topics from where and when veneers are appropriate to reviewing the cementations and finishing of adhesively retained restorations, and everything in between.

Offering 12 CE credits, courses run from 8:30am – 12:30pm, leaving plenty of time to soak up the sunshine! Breathtaking vistas, historic sites and natural landmarks offer unique experiences for everyone’s preferences or pleasures. The beautiful and pristine beaches are perfect for those longing for a peaceful, restorative retreat. Those looking for adventure will find it in the many explorations and excursions Aruba has to offer, such as scuba diving, snorkeling, kite surfing, water skiing, tubing, parasailing and more. Whether you’re looking for a luxurious getaway, or an adventurous escape, an Aruba vacation will be sure to please.

So don’t delay, Early Bird Registration ends November 30, 2018 – we hope to see you all there!

For more information and to register for the 2019 Aruba Dental Conference, please contact Irene Lamonde at 1-800-265-3444 ext. 223 or register online at www.arubadentalconference.com.

About CLINICIAN'S CHOICE DENTAL PRODUCTS, INC.

For over 20 years, CLINICIAN’S CHOICE DENTAL PRODUCTS INC. has been providing dentists throughout North America with clinically proven products and techniques designed to solve the everyday clinical challenges of their esthetic restorative procedures. The promotion of better dentistry forms the core of the company’s values and is demonstrated by an on-going commitment to the presentation of clinical seminars, workshops, and scientific research studies.







Periodontal disease bacteria may kick-start Alzheimer’s

Posted on Thursday, October 4, 2018

Long-term exposure to periodontal disease bacteria causes inflammation and degeneration of brain neurons in mice that is similar to the effects of Alzheimer’s disease in humans, according to a new study from researchers at the University of Illinois at Chicago.

The findings, which are published in PLOS ONE, suggest that periodontal disease, a common but preventable gum infection, may be an initiator of

Alzheimer’s, which currently has no treatment or cure.

“Other studies have demonstrated a close association between periodontitis and cognitive impairment, but this is the first study to show that exposure

to the periodontal bacteria results in the formation of senile plaques that accelerate the development of neuropathology found in Alzheimer’s patients,” said Dr. Keiko Watanabe, professor of periodontics at the UIC College of Dentistry and corresponding author on the study.

“This was a big surprise,” Watanabe said. “We did not expect that the periodontal pathogen would have this much influence on the brain, or that the effects would so thoroughly resemble Alzheimer’s disease.”

To study the impact of the bacteria on brain health, the Watanabe and her colleagues — including Dr. Vladimir Ilievski, UIC research assistant professor and co-author on the paper — established chronic periodontitis, which is characterized by soft tissue damage and bone loss in the oral cavity, in 10 wild-type mice. Another 10 mice served as the control group. After 22 weeks of repeated oral application of the bacteria to the study group, the researchers studied the brain tissue of the mice and compared brain health.

The researchers found that the mice chronically exposed to the bacteria had significantly higher amounts of accumulated amyloid beta — a senile plaque found in the brain tissue of Alzheimer’s patients. The study group also had more brain inflammation and fewer intact neurons due to degeneration.These findings were further supported by amyloid beta protein analysis, and RNA analysis that showed greater expression of genes associated with inflammation and degeneration in the study group. DNA from the periodontal bacteria was also found in the brain tissue of mice in the study group, and a bacterial protein was observed inside their neurons.

“Our data not only demonstrate the movement of bacteria from the mouth to the brain, but also that chronic infection leads to neural effects similar to Alzheimer’s,” Watanabe said.

The researchers found that the mice chronically exposed to the bacteria had significantly higher amounts of accumulated amyloid beta — a senile plaque found in the brain tissue of Alzheimer’s patients. The study group also had more brain inflammation and fewer intact neurons due to degeneration.

These findings were further supported by amyloid beta protein analysis, and RNA analysis that showed greater expression of genes associated with inflammation and degeneration in the study group. DNA from the periodontal bacteria was also found in the brain tissue of mice in the study group, and a bacterial protein was observed inside their neurons.

“Our data not only demonstrate the movement of bacteria from the mouth to the brain, but also that chronic infection leads to neural effects similar to Alzheimer’s,” Watanabe said.

The researchers say these findings are powerful in part because they used a wild-type mouse model; most model systems used to study Alzheimer’s rely on transgenic mice, which have been genetically altered to more strongly express genes associated with the senile plaque and enable Alzheimer’s development.

“Using a wild-type mouse model added strength to our study because these mice were not primed to develop the disease, and use of this model gives additional weight to our findings that periodontal bacteria may kick-start the development of the Alzheimer’s,” Watanabe said.

The researchers say that understanding causality and risk factors for the development of Alzheimer’s is critical to the development of treatments, particularly when it comes to sporadic, or late-onset disease, which constitutes more than 95 percent of cases and has largely unknown causes and mechanisms.

While the findings are significant for the scientific community, Watanabe said there are lessons for everyone.

“Oral hygiene is an important predictor of disease, including diseases that happen outside the mouth,” she said. “People can do so much for their personal health by taking oral health seriously.”

Additional co-authors on the paper are Paulina Zuchowska, Stefan Green, Peter Toth, Michael Ragozzino, Khuong Le and Haider Aljewari of UIC, and Neil O’Brein-Simpson and Eric Reynolds of the University of Melbourne.







Second Annual NuSmile Summit Set for February 15-16, 2019

Posted on Thursday, October 4, 2018

NuSmile Ltd., the worldwide leader in pediatric esthetic restorative dentistry, announced today that the second annual NuSmile Summit will be held February 15-16, 2019 in Clearwater Beach, Florida. The event’s format allows doctors and their team members to create their own schedule by choosing the specific courses that best meet their individual needs. Attendees will receive up to 16 continuing education credits from a combination of hands-on and lecture courses taught by several of the world’s most respected pediatric dentistry experts.

“When we conceived the NuSmile Summit over two years ago, our vision was a simple one: to create the premier continuing education event in pediatric dentistry,” said Diane Johnson Krueger, NuSmile founder and CEO. “The response we got from attendees of last year’s inaugural event told us we were on the right track, leading us to add a whole new Dental Team Member Curriculum. We’re convinced that this year’s Summit will be the finest event of its kind ever held.”

“We’re very excited to invite dental team members to attend our Summit courses and learn from the distinguished experts we’ve been able to assemble to lead them,” said Mike Loessberg, NuSmile Director of Sales, U.S. and Canada. “We’re especially proud our ‘Progressive Esthetics’ hands-on workshop, which provides everything doctors and their teams need to know about pediatric esthetic crown treatment.” According to Mr. Loessberg, workshop topics include treatment planning and the Express Prep technique, as well as high-yield, detail- oriented tips and tricks around proper cementation of pediatric zirconia and pre-veneered crowns.

Throughout the course of the Summit, doctors and their staffs will be able to choose from an unmatched array of course options: 

Doctor curriculum (up to 16 CE credits)

• “Esthetic Primary Crowns and Silver Diamine Fluoride (SDF): A Perfect Match” (LaRee Johnson, DDS, MS)

• “Radiographic Findings in Pediatric Diseases” (Shailesh Kottal, DDS)

• “Managing Those Hair Pulling Out, Drive You to Drink, Make You Want to Scream Situations in Pediatric Dentistry (Bill Waggoner, DDS, MS)

• “New Approaches to Pediatric Pulp Therapy” (Jessica Lee, DDS, MPH, PhD)

• “Pedonomics and Pedometrics” (Roger G. Sanger, DDS, MSD)

• “Managed Care Insurance and Pediatric Dentistry – Opportunities or Problems?” (Dr. Sanger)

• “Advanced Zirconia Treatment Cases” (David Evans, DMD / David Salar, DMD / Eric Ellis, DMD)  Dental team curriculum (up to 14 CE credits)

• “Infection Control – Do You Know the Nitty Gritty?” (Rhea Haugseth, DMD)

• “Parents – Are Yours Backseat Drivers?” (Dr. Haugseth)

• “Know it, Show it and Sell it – Getting Parents to Say Yes” (Dr. Haugseth)

• “Telling your Story on Facebook and Instagram” (Scott Childress)

• “Big Bad Fluoride – Why the Controversy?” (Stacey Zaikoski, DDS)

• “Behavior Guidance for the Pediatric Dental Team” (Dr. Zaikoski)  Hands-on workshop (full day)

• “Progressive Esthetics” (David Salar, DMD; David Evans, DMD; Eric Ellis, DMD)

The event’s keynote speaker will again be Gary Zelesky, who will speak on the theme, “Developing Passionate Leadership, Leading Passionate Lives.” Mr. Zelesky’s presentation at last year’s NuSmile Summit helped convince Twana Duncan, DDS of Antlers, OK to bring her 14-person staff to the 2019 Summit. “I found his speech to be so inspirational that I immediately thought, if my team could hear this, we would definitely be having a lot more positivity in our morning planning meetings,” said Dr. Duncan. “Also, we have a lot of new staff members, and they need to be able to talk knowledgeably to our parents and explain things like why we’re recommending a zirconia crown even though it might not be covered by the patient’s insurance. I also knew that my staff would feel comfortable asking questions in the Summit environment.”

The 2019 NuSmile Summit will again take place at the luxurious Grand Wyndham Resort in Clearwater Beach, Florida, named the “#1 Beach in the U.S.” by Trip Advisor. To take full advantage of this beautiful location, Summit attendees will have the option of participating in several fun activities, including Friday morning yoga on the beach, a Friday afternoon beach party, a Friday sunset reception at the pool, a Saturday morning 3K run, and a Saturday afternoon beach/pool party. NuSmile will be awarding three residents scholarships to attend the 2019 NuSmile Summit. The scholarship includes registration, Thursday & Friday night hotel accommodations, breakfast & lunch for Friday and Saturday, as well as all of the extracurricular events scheduled for the weekend. Doctors and their teams may pre-register for the event by calling 800-346-5133 or visiting nusmile.com.

About NuSmile

Founded in 1991 in Houston, Texas by Diane Johnson Krueger, NuSmile is the worldwide leader in pediatric esthetic restorative dentistry. Shortly after its founding, the company invented its first esthetic pediatric crown;more than 4 million have been used in restorations in the 25 years since. The company’s current offerings include the NuSmile ZR Zirconia crown system, featuring Try-In crowns to prevent saliva/blood contamination and NuSmile BioCem® BioActive Cement for exceptional bond strength and handling; NuSmile Signature Preveneered crowns; NuSmile SSC Pre-contoured crowns; and NuSmile NeoMTA® pulp therapy medicament. NuSmile prides itself on its passion for customer care, its unwavering commitment to research, and its unmatched support for American Academy of Pediatric Dentistry (AAPD), the International Association of Pediatric Dentistry (IAPD), the Canadian Academy of Pediatric Dentistry/Académie Canadienne de Dentisterie Pédiatrique (CAPD/ACPD), the Institute for Pediatric Dentistry (IPD) and several other organizations dedicated to the dental care of children and the dentists who serve them.







New Technique Uses Umbilical Cord Stem Cells for Early Repair of Cleft Palate

Posted on Wednesday, October 3, 2018

Newswise — October 2, 2018 – A technique using umbilical cord blood stem cells could be a promising new approach for repair of cleft palate in infants, reports a paper in The Journal of Craniofacial Surgery, published in the Lippincott portfolio by Wolters Kluwer

Performed as part of reconstructive surgery when the infant is a few months old, the stem cell procedure provides good results in growing new bone to close the upper jaw cleft – and may avoid the need for later bone graft surgery, according to the case report by Alejandro Garcia Botero, MD, of Hospital De San José, Bogota, Colombia, and colleagues.  

Stem Cells Could Be New Option for Closure of Alveolar Cleft 

Dr. Botero and colleagues report their experience with the stem cell procedure in an infant with cleft lip and palate, diagnosed by ultrasound before birth. The baby girl had an alveolar cleft, involving an area of bone where teeth are located. 

Immediately after delivery, a sample of the infant's umbilical cord blood was collected to isolate stem cells, which were processed and frozen to preserve them for later use. Umbilical cord blood is a rich source of various types of stem cells, which have the potential to develop into many different types of specialized cells, including bone and cartilage. 

"Since the age is that of the newborn, [umbilical cord stem cells] have a greater potential to regenerate the organism," Dr. Botero and coauthors write. For the first few months, the infant underwent a nonsurgical "nasoalveolar shaping" procedure to align the soft tissues of the upper jaw. 

At age five months, the stem cells were thawed for use as part of "boneless bone grafting" surgery (gingivoperiostioplasty). The stem cells were placed in a pocket of soft tissue bridging the gap in the upper jaw. A small piece of absorbable biomaterial (Gelfoam) was used a scaffold to guide growth of new bone across the cleft palate. This procedure was performed at the same time as surgery to correct the cleft lip (cheiloplasty). 

Follow-up confirmed formation of new bone to close the cleft palate, providing good position and support for normal eruption of the teeth. Imaging scans when the patient was five years old showed good thickness of the upper jaw bone in the area where the cleft had been. 

A major potential advantage of the stem cell procedure is avoiding the need for later bone grafting surgery – currently the standard technique for closing the cleft. This procedure uses bone taken from elsewhere in the child's body, typically the hip. Bone grafting has potential complications and subjects the child to one or more additional surgeries.  

The study is the first to use stem cells as part of primary surgery to repair cleft palate in an infant. Dr. Botero and colleagues note that their patient will need further monitoring to ensure adequate bone thickness in the upper jaw. The researchers emphasize the need for further studies evaluating their stem cell technique in a large number of patients – including steps to confirm that bone formation results from the stem cells, and not from the initial "boneless bone graft" surgery. 

Click here to read “Importance of Stem Cell Transplantation in Cleft Lip and Palate Surgical Treatment Protocol”

About The Journal of Craniofacial Surgery 

The Journal of Craniofacial Surgery, under the guidance of Editor-in-Chief Mutaz Habal, MD, serves as a forum of communication for all those involved in craniofacial and maxillofacial surgery. Coverage ranges from practical aspects of craniofacial surgery to the basic science that underlies surgical practice. Affiliates include 14 major specialty societies around the world, including the American Association of Pediatric Plastic Surgeons, the American Academy of Pediatrics Section of Pediatric Plastic Surgery, the American Society of Craniofacial Surgeons, the American Society of Maxillofacial Surgeons, the Argentine Society of Plastic Surgery Section of Pediatric Plastic Surgery, the Asian Pacific Craniofacial Association, the Association of Military Plastic Surgeons of the U.S., the Brazilian Society of Craniofacial Surgeons, the European Society of Craniofacial Surgery, the International Society of Craniofacial Surgery, the Japanese Society of Craniofacial Surgery, the Korean Society of Craniofacial Surgery, the Thai Cleft and Craniofacial Association, and the World Craniofacial Foundation. 

About Wolters Kluwer 

Wolters Kluwer is a global leader in professional information, software solutions, and services for the health, tax & accounting, finance, risk & compliance, and legal sectors. We help our customers make critical decisions every day by providing expert solutions that combine deep domain knowledge with specialized technology and services. 

Wolters Kluwer, headquartered in the Netherlands, reported 2017 annual revenues of €4.4 billion. The company serves customers in over 180 countries, maintains operations in over 40 countries, and employs approximately 19,000 people worldwide. 

Wolters Kluwer Health is a leading global provider of trusted clinical technology and evidence-based solutions that engage clinicians, patients, researchers and students with advanced clinical decision support, learning and research and clinical intelligence. For more information about our solutions, visit https://healthclarity.wolterskluwer.com and follow us on LinkedIn and Twitter @WKHealth.







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