The Evolution of Colgate Total®: A New Era Stabilized by Nitrate and Phosphates
Lisa M. Manus, PhD; Carl P. Myers, PhD; Robert D’Ambrogio, BS; Gokul V. Govindaraju, PhD; Guofeng Xu, PhD; Yun-Po Zhang, PhD, DDS (Hon); and James G. Masters, PhD
Abstract: Effective and accessible oral care strategies, like the use of a multi-benefit, antimicrobial toothpaste, are a key tool in preventive public health. For over 30 years, Colgate Total toothpastes have represented a gold standard in multi-benefit toothpastes to help fight bacteria and provide whole-mouth care. This review introduces the next generation of Colgate's research and development featuring stannous fluoride (SnF2) stabilized by nitrate and phosphates. The uniqueness of this engine is detailed through a review of SnF2 oral benefits, the historic challenges associated with SnF2 toothpastes, and the advantages that this chemistry can bring to patients seeking multi-benefit oral care. With this novel technology, a new balance in efficacy, stability, and streamlined design enables flexible formulation and customized user experiences inspired by key therapeutic areas.
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Please scan the QR code or visit aegisdentalnetwork.com/go/colgate2 to view the full article and reference list as well as acknowledgments, disclosures, data availability statement, and author information. The article goes on to discuss Colgate’s next-generation stannous fluoride dentifrice stabilized by nitrate and phosphates (SNaP). This breakthrough stabilization technology offers a streamlined, efficacious approach to SnF2 stability and bioavailability, with enhanced formulation flexibility for broad versatility in flavors, cooling agents, esthetics, and foaming profiles.
